Our Research

Pioneering Leadership in AI, Computational Biomedicine and Data Analytics

At RRI, we've pioneered models that optimize anemia management and help reduce hospitalizations. We’ve published over 600 peer-reviewed studies since 2000—contributing not only to innovation but to a growing body of evidence-based science that shapes practice and policy.

Our mathematical modeling work includes building realistic virtual trials based on physiological models that are married with both patient and operational data. These simulations enable us to test the safety and effectiveness of multiple treatment protocols on millions of patient avatars — something that would be absolutely impossible in a real-world clinical trial.

We are at the forefront of developing AI tools that support clinicians and improve outcomes for patients. On an operational level, this includes utilizing large language models to assist physicians in collecting information more efficiently and to spend more time with their patients. In the area of pure innovation, our interdisciplinary team and agile development process enable us to explore promising ideas that are not yet connected to a clinical application.

Because our data spans over 20 countries, we also have a unique opportunity to answer global questions using large, comprehensive datasets. We use advanced analytics to evaluate the effectiveness of specific healthcare interventions and explore the potential of new clinical strategies, treatments, protocols, and diagnostic tools. The range of issues we explore, the different perspectives and areas of expertise we draw on, and the quality of our data all contribute to the breadth and depth of our published studies.

Research Innovations

The MONDO Initiative

At the beginning of the MONitoring Dialysis Outcomes (MONDO) initiative stood an unexpected discovery in U.S. hemodialysis patients: In the months before death, clinical and laboratory parameters showed characteristic dynamic patterns. Motivated by this finding and to evaluate its generalizability, RRI and several of its collaborators decided to conduct similar studies in other regions of the world. To that end, they launched the MONDO initiative in 2010. Over the years, the initiative grew into a multinational collaboration between dialysis providers and academic institutions.

The MONDO initiative is open to partners willing to share data and academic researchers. MONDO has become one of the largest international dialysis databases. It currently comprises 41 countries on 6 continents and allows for analysis of longitudinal, treatment-level data in around 200,000 dialysis patients. Next to treatment and outcome data, the MONDO database contains a multitude of assessment ranging from lab measurements to bioimpedance spectroscopy assessments, consequently allowing for a wide range of epidemiological research.

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MyNCBI

The Renal Research Institute scientific research output comprises hundreds of publications in peer review journals. Citations may include links to full text content from MyNCBI/PubMed and publisher web sites.

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